Constraints in total knee arthroplasty: current status and review of literature

Appropriate selection of prosthesis is critical for success of total knee arthroplasty. It is a daunting task of arthroplasty surgeon to choose from a wide array of implant design for a given situation to confer optimal stability, which translates into satisfactory outcome. Contemporary evolution of prosthetic design with various levels of constraints has revolutionized the approach to total knee arthroplasty. This paper deals with the succinct review of the level of constrained prosthesis available for knee arthroplasty

Histopathology of gill, liver, muscle and brain of Cyprinus carpio communis L. exposed to sublethal concentration of lead and cadmium

Histological studies in organs like gill, liver, muscle and brain of Cyprinus carpio communis were made to assess tissue damage due to sublethal concentration of heavy metals lead and cadmium after 28 days of exposure. In lead treated gill, disintegration and fusion of primary lamellae, extensive vacuolization with disruption of epithelial lining was observed, whereas on sublethal exposure to cadmium, hyperplasia of branchial arch, vacuolization and congestion of blood vessels were well marked. Metal accumulation was clearly visible in treated liver with degeneration and severe necrosis. Both lead and cadmium treated fish showed marked thickening and separation of muscle bundles with severe intramuscular oedema more pronounced in sublethal treatment of cadmium. Neuronal cell degeneration, swelling of pyramidal cells, vacuolization and dystrophic changes were characteristic features observed in treated brain.Key words: Lead, cadmium, histopathology, Cyprinus carpio communis

Wideband Josephson Parametric Isolator

The cryogenic hardware required to build a superconducting qubit based quantum computer demands a variety of microwave components. These elements include microwave couplers, filters, amplifiers, and circulators/isolators. Traditionally implemented as discrete components, integration of this peripheral hardware, in an effort to reduce overall footprint, thermal load, and added noise, is a key challenge to scaling modern quantum processors with qubit counts climbing over the 100+ mark. Ferrite--based microwave isolators, generally employed in the readout chain to decouple qubits and resonators from readout electronics, persist as one of the volumetrically largest devices still utilized as discrete components. Here we present an alternative two--port isolating integrated circuit derived from the DC Superconducting Quantum Interference Device (DC--SQUID). Non--reciprocal transmission is achieved using the three--wave microwave mixing properties of a flux-modulated DC--SQUID. We show that when multiple DC--SQUIDs are embedded in a multi--pole admittance inverting filter structure, the three--wave mixing derived from the flux pumping of the DC--SQUIDs can provide directional microwave power flow. For a three--pole filter device, we experimentally demonstrate a directionality greater than 15 dB over a 600 MHz bandwidth.Comment: 16 pages, 10 figure

1′-Methyl-4′-(4-methyl­phen­yl)dispiro­[1-benzopyran-3(4H),3′-pyrrolidine-2′,3′′-indoline]-2,2′′-dione

In the title compound, C27H24N2O3, the pyrroldine ring adopts a twist conformation, while the six-membered pyran­one ring of the coumarin ring system is in a sofa conformation. In the crystal, pairs of N—H⋯O hydrogen bonds link the mol­ecules into inversion R 2 2(8) dimers. These dimers are further connected via C—H⋯O hydrogen bonds

Effects of steady state free precession parameters on cardiac mass, function, and volumes

G0400444/Medical Research Council/United Kingdom Wellcome Trust/United Kingdo

Demonstration of Universal Parametric Entangling Gates on a Multi-Qubit Lattice

We show that parametric coupling techniques can be used to generate selective entangling interactions for multi-qubit processors. By inducing coherent population exchange between adjacent qubits under frequency modulation, we implement a universal gateset for a linear array of four superconducting qubits. An average process fidelity of $\mathcal{F}=93\%$ is estimated for three two-qubit gates via quantum process tomography. We establish the suitability of these techniques for computation by preparing a four-qubit maximally entangled state and comparing the estimated state fidelity against the expected performance of the individual entangling gates. In addition, we prepare an eight-qubit register in all possible bitstring permutations and monitor the fidelity of a two-qubit gate across one pair of these qubits. Across all such permutations, an average fidelity of $\mathcal{F}=91.6\pm2.6\%$ is observed. These results thus offer a path to a scalable architecture with high selectivity and low crosstalk